Esben Stistrup Lauritzen
M.D., PhD student (enrolled 2018)
Deparment: Medical/Steno Research Laboratory
Main supervisor: Niels Møller
- Pathophysiology and diabetes pharmacology
- Acute and chronic metabolic effects of melatonin
Good sleep and synchrony between the internal circadian rhythm and the external day-night cycle is crucial for well-regulated glucose homeostasis exemplified by an increased risk of type 2 diabetes in night-shift workers. Melatonin serves as a light-sensing neurohormone, which translates retinal light exposure to an endocrine signal. It is mainly secreting during the night where it promotes sleep, but several lines of evidence also suggest that it is involved in the regulation of glucose homeostasis. I investigate the relationship between melatonin and glucose homeostasis after acute daytime administration as well as the metabolic consequences of long-term melatonin administration before bedtime in patients with type 2 diabetes.