Tine Borup Billeskov
M.D., PhD student (enrolled 2018)
tine@clin.au.dk
Department: Endocrinology and Steno Diabetes Center Aarhus, Aarhus University Hospital
Main supervisor: Jens Otto L. Jørgensen
Research Area
- Intersectorial research (Tværs)
Research description
- Effects of growth hormone and IGF-1 on anabolic signals and stem cell recruitment in human skeletal muscle
Growth hormone is an important regulator of substrate metabolism and muscle mass. Skeletal muscle metabolism is a major determinant of overall resting energy expenditure and is able to rapidly shift between carbohydrate and fat oxidation. Maintenance of human skeletal muscle mass is crucial not only for ambulatory activities of daily living, but also for protection against pathologies such as cardiovascular diseases and type II diabetes. In addition, it is estimated that skeletal muscle accounts for up to 85% of overall insulin-stimulated glucose uptake after a glucose load, and normal muscle function is essential for regulation of whole body.