Steno Thursdays Global - Research Seminars
Steno Diabetes Center Aarhus presents 'Steno Thursdays Global'; a monthly seminar series with international diabetes experts and both a live and online audience
Steno Diabetes Center Aarhus presents 'Steno Thursdays Global'; a monthly seminar series with international diabetes experts and both a live and online audience.
The topics will reflect our broad research interest at Steno Diabetes Center Aarhus from clinical- and biomedicine to epidemiology. A chairperson will facilitate discussion after the talk involving also the online audience.
Our ambition is to facilitate a global forum for discussion of hot topics in diabetes research in a new hybrid format combining the advantages of live and virtual events.
Upcoming events
Past events
Topic
- Decoding tissues at multiple scales
Speaker
- Victor Puelles, M.D., Professor and group leader at University Medical Center Hamburg-Eppendorf and Dept. of Pathology, Aarhus University
Summary
- The significance of spatial context is rising in the scientific community. Our team works on methods for structural and molecular profiling of tissues across biological scales, from 3D whole organs to subcellular compartments. In this session, we'll discuss these technologies and their applications in experimental and translational projects.
Time
- November 9, 14:15-15:00
Location
- Steno Diabetes Center Aarhus, Verdensrummet (A201-170)
Topic
- Cold-inducible proteome changes as novel rheostat for brown fat function.
Speaker
- Jan-Wilhelm Kornfeld, DDA Prof. of Molecular Biology of Metabolic Diseases, Group leader, University of Southern Denmark
Summary
- By performing epigenomic profiling and Nanopore RNA-Sequencing we unveiled hitherto unknown Adenylyl Cycase protein isoforms that are key to understanding brown fat function in mice and humans. We demonstrate fundamentally new roles for these proteoforms in rheostatic regulation of brown fat using a combination of biochemical interaction assays, protein modelling and tailored transgenic mouse models.
Time
- September 28, 14:14-15:00
Location
- Steno Diabetes Center Aarhus, Verdensrummet (A201-170) or by Zoom
Topic
- Regulation of lipid and lipoprotein metabolism by brown adipose tissue Location: Steno Diabetes Center Aarhus, Verdensrummet (A201-170) and through Zoom with registration.
Speaker
- Jörg Heeren, Dr. rer. nat. Dipl.-Biochem, Heisenberg Professor at University Medical Center Hamburg
Summary
- Brown adipose tissue has profound metabolic effects and can lower blood triglycerides and atherogenic lipoprotein levels. In the context of cardiometabolic disease, activation of Brown adipose tissue favorably affects atherosclerosis, lipoprotein remodeling, and cholesterol metabolism. By using state-of-the-art technologies to visualize and quantify metabolite flux, Prof. Heeren will share recent data how systemic and local mechanisms control energy metabolism and adipose tissue homeostasis under conditions of adaptive thermogenesis.
Time
- June 22, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus, Verdensrummet (A201-170) or through Zoom
Topic
-
Using genetic aetiology to guide treatment of diabetes: lessons from the Inuit population of Greenland.
Summary
-
Marit has been conducting epidemiological research since 1996, focusing on the correlation between social transition, lifestyle, genetics, environment, and chronic diseases, mainly diabetes, obesity, and cardiovascular disease in the Inuit population of Greenland. Currently, Marit is working on merging unbiased clinical data with register-compiled information to establish a solid quantitative background for diabetes-related health research.
Speaker
-
Marit Eika Jørgensen, Professor, Steno Diabetes Center Greenland.
Time
-
May 25, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus, Verdensrummet (A201-170) or through Zoom with registration.
Title
- Towards personalized therapies in childhood diabetes
Summary
- Childhood diabetes poses a significant burden on children and parents due to complex treatments and potential complications. Typically, children with diabetes are assumed to have type 1 and receive lifelong insulin treatment. However, recent genetic advances suggest that some may have a subtype better treated with oral drugs rather than insulin injections.
Speaker
- Pål Rasmus Njølstad, M.D., PhD, Center Leader at Mohn Center for Diabetes Precision Medicine, Univ. of Bergen
Time
- May 4, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus, Verdensrummet (A201-170) or through Zoom with registration.
Topic
- The Glymphatic System at the Interface between the Central and Peripheral Nervous System.
Summary
- Maiken Nedergaard is a Danish neuroscientist famous for discovering the glymphatic system a network of channels in the brain whose purpose is to eliminate toxins using cerebrospinal fluid.
Speaker
- Maiken Nedergaard, M.D., D.M.Sc., Center for Translational Neuromedicine, University of Cogenhagen
Time
- March 16, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Forum, AUH) or via Zoom
Topic
- GLP-1: How and where does it work?
Summary
- Daniel Drucker is renowned internationally for his work on gastrointestinal hormones in relation to obesity and type 2 diabetes. His lab carries out studies on the physiology and mechanism of action of hormones - encompassing glucagon and GLP-1 - in a pathophysiological context.
Speaker
- Daniel J. Drucker, MD, Professor of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
Time
- September 29, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Forum, AUH) or via Zoom
Topic
- Using continuous glucose monitoring to support behavior change in type 2 diabetes
Summary
- Continuous Glucose Monitoring (CGM) has historically been used primarily for people with Type 1 Diabetes to assist with insulin dosing. Newer, more user friendly, and cheaper CGM technology may help people with Type 2 Diabetes who are working on behavior change. Early randomized controlled trial evidence suggests it can work in a primary care setting and may be cost saving due to medication deintensification.
Speaker
- Caroline Richardson, MD, Research Professor, Associate Chair of Research, Department of Family Medicine, University of Michigan, US
Time
- June 9, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Sex differences in lipid and lipoprotein metabolism
Summary
- In this talk we will discuss the physiologic basis for sex-differences in normal physiology and disease. We will discuss common sex-differences in metabolism and cardiovascular disease. I will share work from our group related to mechanisms for sex differences in fatty liver, dyslipidemia and atherosclerosis.
Speaker
- John Stafford, MD, PhD, Associate Professor, Vanderbilt University School of Medicine, US
Time
- May 12, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Prediabetes: paradigm or paradox?
Speaker
- Kristine Færch, Research Leader & Professor, Clinical Prevention Research Group, Steno Diabetes Center Copenhagen & University of Copenhagen
Time
- April 28, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Exercise and insulin action - when it gets personal(ized)
Summary
-
The interaction between exercise and insulin action has been acknowledged since the discovery of insulin 100 years ago.
While this interaction can negatively impact the daily life of insulin treated physically active individuals, it also constitutes an opportunity for individuals with peripheral insulin resistance to improve glycemic control. Lately, the pharmaceutical industry has recognized a significant therapeutic potential in uncovering the mechanisms underlying the insulin/exercise interaction. This presentation will illuminate current knowledge within this field, how it was unearthed through animal modeling and invasive human studies, and by which means recent breakthroughs has crystallized into a new promising area that we coined Personalized Phosphoproteomics.
Speaker
- Jørgen Wojtaszewski, Professor & Head of Section, Department of Nutrition, Exercise and Sports, University of Copenhagen
Time
- March 31, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Deep digital phenotyping of people with diabetes
Speaker
- Guy Fagherazzi, Director of the Department of Population Health & Group Leader of the Deep Digital Phenotyping Research Unit, Luxembourg Institute of Health
Time
- February 10, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Overview of the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute of MIT and Harvard
Summary
-
The Novo Nordisk Foundation and Broad Institute of MIT and Harvard have launched a new research Center for Genomic Mechanisms of Disease, an initiative that will accelerate efforts to mine genetic data for insights into disease mechanisms – and eventually, rationally designed treatments.
Supported by a $47.5 million commitment from the Novo Nordisk Foundation, the Center will facilitate close collaborations between the Broad Institute and Danish researchers investigating the genetics and gene regulation of common complex disease, with an initial focus on type 2 diabetes and obesity. The Center will align with existing international efforts, data sharing, methodology, and tools to contribute to the roadmap of the International Common Disease Alliance, and working in common cause with investigators from other large-scale efforts such as the Accelerating Medicines Partnership in Common Metabolic Diseases and the Impact of Genomic Variation on Function consortia.
The research collaboration of the Center aims to advance patient-centered research and precision medicine. The Center will establish an exchange program to provide opportunities for Danish scientists to study genomic technologies at the Broad Institute. In turn, these collaborations will catalyze and contribute to expanding biomedical research in Denmark. The new Center is directed by Kasper Lage, who has played an important role in the planning and development of the initiative.
Speaker
- Kasper Lage, PhD, MBA, Managing Director of the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease; Director of Bioinformatics at the Department of Surgery, Massachusetts General Hospital; Associate Professor at Harvard Medical School, and in the Leadership Group of the Stanley Center for Psychiatric Research at Broad Institute
Time
- November 11, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Metabolic comorbidity in schizophrenia spectrum disorders (SSDs):
a collision of brain and body?
Objectives
- Review the associations between SSDs and high rates of type 2 diabetes
- Recognize the contributing effects of antipsychotic treatments, including perturbations of central nervous system control of metabolic homeostasis
- Discuss the clinical implications of metabolic disorders in SSDs, moving to novel treatment opportunities
Speaker
- Margaret Hahn, Associate Professor at the Institute of Medical Science, University of Toronto
Time
- October 7, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Measuring comorbidity related to mental disorders – update on methods with particular reference to endocrine disorders
Speaker
- John McGrath, Niels Bohr Professor at the National Centre for Register-based Research, Deptartment of Economics and Business Economics, Aarhus University & Director of the Queensland Centre for Mental Health Research, Australia
Time
- September 9, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) or via Zoom
Topic
- Chronic heart failure and diabetes
Summary
- Heart failure frequently coexist with type 2 diabetes. Current treatment involves metformin, SGLT2i and more in HFrEF, but in HFpEF there is an unmet need. There is need for targeted ‘precision’ medicine in HFpEF as there are striking differences in their respective disease pathophysiology.
Speaker
- Chim Lang, Clinical Professor, University of Dundee, UK
Time
- June 17, 2021, 14:15-15:00 (CET)
Location
- Zoom
Topic
- When does the clock for diabetic microangiopathy start ticking? – insights from the Maastricht Study
Summary
- Microangiopathy in diabetes has many more manifestations than retinopathy, nephropathy and neuropathy. For example, microangiopathy contributes to cognitive impairment, late-life depression and heart failure, which are all more frequent in people with than in those without diabetes. Microvascular dysfunction precedes clinical microangiopathy and can consistently be shown to be already present in people with prediabetes. In fact, the association between microvascular dysfunction and glycaemia appears to be continuous, without a clear threshold. Additionally, microvascular dysfunction in skeletal muscle and in pancreatic islets is thought to impair insulin-mediated glucose uptake and glucose-stimulated islet function, respectively, and thus contribute to diabetes onset and progression. Obesity, in turn, is an important contributor to microvascular dysfunction. Because obesity usually precedes type 2 diabetes by many years, the clock for diabetic microangiopathy may start ticking decades before onset of type 2 diabetes.
Speaker
- Coen Stehouwer, Professor of Internal Medicine and Chair of the Department of Internal Medicine, Maastricht University, NL
Time
- June 3, 2021, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (Hedeager 3) & Zoom
Topic
- Health quality registries - Platforms for improving care and conducting clinical trials
Summary
- National health registries are instrumental in improving quality of care but only few countries utilize this potential. In addition, registries with high data quality can be used as platforms for conducting high-volume, low-cost randomized trials. This talk will describe how Swedish health registries have contributed to improving care and change of guidelines.
Speaker
- Ole Fröbert, Consultant cardiologist, Örebro University Hospital, Sweden
Time
- May 20, 2021, 14:15-15:00 (CET)
Location
- Zoom
Topic
- Genotypic and phenotypic variation in T2DM - implications for management
Summary
- Whilst the current guidelines for the pharmacological management of diabetes acknowledge the need to personalise treatment in diabetes, there is little evidence to guide therapeutic choice. For a patient in the clinic, are they more likely to respond better to SGLT2 inhibitors or DPP4 inhibitors? Is someone more or less likely to get side effects. This talk will discuss a framework for how we approach precision medicine in diabetes, and discuss phenotypic and genotypic determinants of response or adverse outcome for commonly used diabetes drugs.
Speaker
- Ewan Pearson, Clinical Professor, Population Health and Genomics, School of Medicine, University of Dundee
Time
- May 6, 2021, 14:15-15:00 (CET)
Location
- Zoom
Topic
- Body weight biology and obesity pharmacology
Summary
- An enhanced understanding of the physiological and molecular underpinnings of energy homeostasis is necessary for the development of the next generation of efficacious pharmacological weight loss agents. The identification of novel circulating factors, important for weight homeostasis, might open up for the discovery of such novel treatment strategies.
Speaker
- Christoffer Clemmensen, Associate Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, DK
Time
- Apr 29, 2021, 14:15-15:00 (CET)
Location
- Zoom
Topic
- SORLA, sorting out insulin signaling in visceral obesity
Summary
- VPS10P domain receptors are intracellular sorting receptors implicated in various metabolic diseases, including hypercholesterolemia, diabetes, and obesity. We discuss how VPS10P domain receptor SORLA acts as an insulin-sensitizing receptor that defines the propensity of visceral but not subcutaneous white adipose tissue to respond to dietary signals with expansion.
Speaker
- Thomas Willnow, Professor, Department of Biomedicine, Aarhus University & Max-Delbrueck-Center for Molecular Medicine (MDC), Berlin
Time
- March 11, 2021, 14:15-15:00 (CET)
Location
- Zoom
Topic
- Insulin resistance in pregnancy: is it good, bad or really does not matter
Speaker
- Patrick Catalano, MD, Professor, Tufts University School of Medicine, Friedman School of Nutrition, Science and Policy
Time
- February 4, 2021, 14:15-15:00 (CET)
Location
- Zoom
Topic
- Precision medicine in diabetes: Discussion about the recent ADA/EASD Consensus Report
Speakers
-
Paul Franks, Professor & Deputy Director, Lund University Diabetes Center, Sweden
- Daniel Witte, Professor, Steno Diabetes Center Aarhus, Denmark
Time
- December 3, 14:15-15:15 (CET)
Location
- Steno Diabetes Center Aarhus (live event) or via Zoom
Topic
- Insulin resistance in vascular endothelial cells
Summary
- Insulin resistance in vascular endothelial cells causes an activated, pro-inflammatory endothelium. This may contribute to atherosclerosis, impaired angiogenesis and tumor formation in obesity and type 2 diabetes.
Speaker
-
Christian Rask-Madsen, Assistant Professor, Joslin Diabetes Center
Time
- November 5, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (live stream) or via Zoom
Topic
- New treatment options for kidney disease in diabetes
Summary
- After 20 years of unsuccessful attempts to combat diabetic kidney disease, we finally have positive outcome studies with multiple agents reducing renal and cardiovascular events. These new options and the new KDIGO global guideline to ensure implementation will also be discussed.
Speaker
-
Peter Rossing, Professor & Chief Physician, Steno Diabetes Center Copenhagen
Time
- October 8, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (live stream) or via Zoom
Topic
- The changing epidemic of diabetes. Is the epidemic abating?
Speaker
- Dianna Magliano, Professor, Baker Heart & Diabetes Institute and Monash University
Time
- September 10, 14:15-15:00 (CET)
Location
- Steno Diabetes Center Aarhus (live stream) or via Zoom