Joanna Kalucka, PhD
- Endothelial cells
- Cardiovascular disease
- Impaired vascular remodelling, during the expansion of adipose tissue, promotes hypoxia and inflammation leading to increasing occurrences of obesity-related disorders including cardiovascular disorders. Therefore, malfunctional blood vessel has become a clinically recognized as life-threatening incidence in human. Endothelial cells (ECs) are the building blocks of blood vessels.
- Given the emerging importance of understanding the heterogeneity of ECs, by using a multidisciplinary approach, we focus on characterization of ECs heterogeneity in adipose tissue. This study will provide us with the answers on what kind of impact the microenvironment represented by the obese state has on the gene expression in ECs.