Diana Faibesh
PhD student (enrolled March 2024)
Department: Department of Biomedicine, Aarhus University
Main supervisor: Niels Jessen
Research Area
- Diabetic complications
- Nutrition, Obesity and lipid metabolism
- Pathophysiology and diabetes pharmacology
Research description
- Investigating the Role of CD47 Signalling in Cancer Cachexia
Cachexia is a metabolic syndrome sharing similarities with diabetes. Our research focuses on CD47 and THBS1 signalling in cancer cachexia development and its therapeutic potential. Recent studies show that CD47 receptor blockade improves insulin release and links between T2DM and accelerated age-related muscle loss, which is a hallmark of cachexia. T2DM patients also face an increased risk of pancreatic and hepatic malignancies, which are the types with the highest potential to develop to cancer cachexia. Hence, our research could have crucial implications for future diabetic patient treatment.